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KMID : 0379520010170040267
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한국독성학회지
2001 Volume.17 No. 4 p.267 ~ p.272
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Reproductive Toxicity Assessment on 2-Bromopropane using Spematogenesis Stage Classification and Sertoli Cell Indices
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Chung Yong-Hyun
Han Jeong-Hee
Yu Il-Je
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Abstract
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This study was carried out to assess the reproductive toxicity of 2-bromopropane (S-BP) using spermatogenesis stage classification and Sertoli cell indices (SCI).Vehicle control olive oil and 2-BP doses of 125, 250 and 500 mg/kg of body weight were injected in the interaperitoneum of 12 weeks male Sprague-Dawley rats for 28 days respectively of SCI on germ cells including the spermatogonia of stages II-III, Ⅵ,Ⅹ, XII, ⅩIII, and spermatocytes of stages VIII (preleptotene), Ⅹ (leptotene), XII (leptotene), V and Ⅵ (pachytene), and the round spermatids of stage Ⅵ. Considering the process of maturation depletion in spermatonesis, spermatogonia may be the primary target cells of 2-BP toxicity.
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KEYWORD
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-Bromopropane, Reproductive toxicity, Testis, Spermatogenesis, Stage, Sertoli cell indices, S.D. rats
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